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The near-infrared II (NIR-II) area photothermal therapy (PTT) performance of HAuNS@PEG-bio is demonstrated to be effective, and the elevation of temperature at the tumor site stimulates blood circulation to mitigate the hypoxia within the tumor microenvironment (TME) (159)

141 These findings collectively highlight the noticeable relationship between high histone Kla levels and poor prognosis in ocular melanoma, emphasizing its pivotal oncogenic role in ocular malignancy

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3-Hydroxy-3-methylglutaryl-CoA lyase deficiency is a disorder biochemically characterized by the predominant accumulation of 3-hydroxy-3-methylglutarate (HMG), 3-methylglutarate (MGA), 3-methylglutaconate and 3-hydroxyisovalerate in tissues and in vivo administration of HMG and MGA significantly decrease GSH concentration in liver in young rats [25]