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Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects

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used a similar strategy to introduce longer PEG chains ranging from PEG4 to PEG24 into polypeptides by suppressing an amber stop codon 254

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Whether you delay one dose due to a medical procedure or adjust your schedule, your price remains the same