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We hypothesized that TNF- increases glycolysis and in this way controls the expression of IL-6, IL-8, and COX-2 in bFLS

Arginine is neuroprotective through suppressing HIF-1/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury

These compounds form two main metabolite groups: Primary metabolites : These are the compounds involved in physiological functions (body growth and reproduction) and include proteins, lipids, and polysaccharides Secondary metabolites: These are minor compounds that are needed by the body in only trace amounts

Hence the need for loading doses