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Semaglutide, for example, has been shown to reduce the risk of major adverse cardiovascular events such as heart attack and stroke

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The following situations require a clinician conversation or same-day care: Contact within 48 hours if: vomiting prevents you from keeping down water for more than eight hours, diarrhea produces signs of dehydration, constipation has not responded to an osmotic laxative after five days, or symptoms worsen at a stable dose after week 12