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Thirty-four years old
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Arecoline, a component of areca nut, has been shown to induce several pro-carcinogenic changes, including the production of nitrosamines and reactive oxygen species (Moutasim et al., 2011), and increased expression of inflammatory cytokines, including tumor necrosis factor-, interleukin-6, interleukin-8, and interleukin-1- (Chang et al., 2009)
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The latter afrmation would be in consonance with the proposal by Foulds et al., which stated that the instrument could be capable of assessing the dierent patterns used as criteria to diagnose users with problems due to nicotine consumption included in the DSM-V, such as frequency of consumption, motivation, withdrawal, diculty with quitting, and craving
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