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Activated microglia display a neuroprotective phenotype when intracellular cholesterol levels are increased As previously mentioned, specific genetic signatures have been identified within the spectrum of microglial changes associated with neurodegeneration, referred to as DAM and MGnD phenotypes [4, 5]

The body may add scar tissue to make the joint more stable, but the joint may still become painful and arthritic

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Cytochrome P450 4F2 (CYP4F2) initiates -oxidation of tocochromanols, a process that is followed by -oxidation to carboxyethyl hydroxychromanol (CEHC), which can be conjugated with glucuronide or sulfate and excreted in urine or bile