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Dehydration : Manifests as decreased urination, dark urine, dry mouth, dizziness upon standing, and fatigue Cardiovascular symptoms may occur, particularly as secondary effects of dehydration or anxiety: Increased heart rate (tachycardia) Palpitations or irregular heartbeat Lightheadedness or fainting Potential signs of pancreatitis (a rare but serious adverse effect): Severe, persistent abdominal pain, often radiating to the back Pain that worsens after eating Nausea and vomiting that doesn't resolve Tenderness when touching the abdomen Other potential symptoms include: Severe fatigue or weakness Headache Visual disturbances (if hypoglycemia develops) Altered mental status or confusion Symptom onset may begin within hours of injection but often intensifies over 1-2 days, aligning with tirzepatide's pharmacokinetic profile (peak concentration at approximately 24-48 hours)

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See the safety profile of Wegovy in adolescents Get your patients started on Wegovy Important Safety Information for Wegovy WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

As an observational study, the new analysis showed that the GLP-1s are associated with reduced risk of substance use disorders and harms, not that the drugs themselves caused the reduction

Metabolic syndrome in a sub-Saharan African setting: central obesity may be the key determinant