Patients with pre-existing osteoporosis, advanced age, low BMI, or those taking corticosteroids may require closer bone health monitoring during GLP-1 therapy
Inhibited glucagon secretion and suppressed hepatic gluconeogenesis: Glucagon is the hormone that increases blood glucose levels
Eli Lilly $LLY (LLY) said in August that the drug behind Zepbound was found to help nearly eliminate the risk of diabetes for adults who are pre-diabetic and are overweight or obese.The drug was tested on over 1,000 adults who had pre-diabetes and were overweight or obese over the course of three years
Semaglutide mimics the action of the natural protein glucagon-like peptide 1(GLP-1), a hormone from a family of chemical messengers called the incretins, which Belgian physiologist Jean LaBarre first purified as an extract from the gut back in 1929
In the SUSTAIN 2 trial, once-weekly add-on subcutaneous semaglutide was compared with add-on sitagliptin [17]