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By working upstream, it maintains activity throughout the cascade rather than substituting at the end stage

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Merck / Cubist ($8.4B, 2014): Patent Invalidation on Announcement Day Cubists Cubicin (daptomycin) generated approximately $1 billion annually, and the acquisition price implied a multiple on that earnings stream consistent with sustained patent protection to 2020

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Nature 498 , 99103 (2013)