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They should not be read as a single clean verdict

Effectiveness of preconception weight loss interventions on fertility in women: a systematic review and meta-analysis

When significant weight loss occursas commonly seen with tirzepatide therapymultiple physiological changes may affect temperature regulation

In particular, neurons of the hindbrain found in the nucleus-tractus solitarius (NTS) secrete GLP-1 and activate hypothalamic neurons of the paraventricular nucleus (PVN), resulting in satiety (155, 156)