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Furthermore, dual and triple receptor agonists, such as tirzepatide and retatrutide, offer additional advantages by targeting multiple pathways involved in energy regulation, resulting in enhanced weight loss and improved metabolic outcomes compared to traditional GLP-1 RAs

Dose escalation is gradual to minimise gastrointestinal side effects such as nausea and vomiting

Given that the Peptide group mimics conventional peptide therapeutics, we anticipate that genome editing-mediated Exe4 secretion could provide similar efficacy to existing GLP-1RA treatments

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