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[9] Consideraciones de seguridad importantes incluyen: Contraindicacin en pacientes con historia personal o familiar de carcinoma medular de tiroides o sndrome de neoplasia endocrina mltiple tipo 2 [1] [2] Consideraciones renales: La mayora de los agonistas GLP-1 (semaglutida, dulaglutida, liraglutida, tirzepatida) no requieren ajuste de dosis por funcin renal