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Broad preclinical activity can be scientifically interesting without automatically translating into safe, predictable, clinically meaningful human outcomes

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This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al

Copper toxicity considerations Copper toxicity from GHK-Cu is extremely unlikely at standard doses but remains a theoretical concern worth understanding