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To examine the role of PI3K/Akt in CM, the PI3K/Ak antagonist LY294002 (20 mg/kg

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These include: Nausea Abdominal pain Diarrhea Vomiting Constipation These side effects are most frequent when starting the medication and when increasing the dose

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They highlight the role of evidence-based pharmacotherapyparticularly GLP-1 receptor agonistsin achieving sustained weight loss and improving cardiometabolic outcomes when used as part of comprehensive, patient-centred care that goes beyond lifestyle intervention alone