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In overweight or obese women with PCOS the majority retatrutides large weight and hepatic-fat reductions would be expected, by analogy and mechanism, to translate into meaningful improvements in hyperinsulinemia and its downstream androgenic consequences

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Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, Weissenborn K, Wong P (2014) Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver