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Obesity SURMOUNT-1 Trial In adults with obesity (without diabetes): Tirzepatide (15 mg) : 20.9% average body weight reduction over 72 weeks Semaglutide (2.4 mg) (based on STEP trials): ~14.9% average reduction STEP 5 Long-Term Results Semaglutide also demonstrated durable effects: At 104 weeks, patients maintained ~15% weight loss on semaglutide 2.4 mg (STEP 5) SELECT Trial Cardiovascular Benefit Semaglutide significantly reduced major adverse cardiovascular events by 20% in people with obesity and pre-existing heart diseaseindicating benefit beyond weight loss
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3.2 Effects of stressors on the brain fatty acid composition The fatty acid composition of the cerebrum tissue in control and stress-exposed rats is summarized in Table 1
The enhanced efficacy of tirzepatide likely stems from its dual mechanism: The addition of GIP receptor activation appears to provide synergistic benefits, potentially through: Enhanced insulin secretion Direct effects on adipose tissue Complementary appetite regulation pathways The Next Frontier: Triple Agonist Research If dual agonism improves upon single agonism, what about triple agonism
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