Resmetirom (Rezdiffra TM ), a liver-directed thyroid hormone receptor- (THR-) agonist, received accelerated FDA approval in March 2024 as the first agent specifically indicated for non-cirrhotic MASH with moderate-to-advanced fibrosis (F2-F3), based on the MAESTRO-NASH trial demonstrating MASH resolution and fibrosis improvement
a few cases have been reported in the oral cavity, half of which became malignant
Receptor Signalling Activates TGF-beta, VEGF, and FGF pathways - coordinating tissue regeneration, vascularisation, and the inflammatory resolution cascade
The 12-week schedule keeps that dose constant while frequency falls: daily in weeks 14, five times weekly in weeks 58, and two or three times weekly in weeks 912
Wang L, Zehir A, Sadowska J, Zhou N, Rosenblum M, Busam K, Agaram N, Travis W, Arcila M, Dogan S, Berger MF, Cheng DT, Ladanyi M, Nafa K, Hameed M