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In combined B12 and folate deficiency, B12 replacement must be started before folate supplementation to avoid precipitating or worsening neurological damage

R GLYAT uses a catalytic His and Asp residue pair to deprotonate the glycine alpha-amino group, making it nucleophilic for attack on the acyl-CoA thioester bond

A libertarian approach to medicine Victor Prisk, an orthopedic surgeon in Pittsburgh, said he understands the appeal of a libertarian approach to medicine, in which patients educate themselves and then make an informed choice about whether to proceed with an unapproved drug

References: Pieren, D

This involved 40 patients