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During the last 2 weeks of the titration periods in those 12 participants, semaglutide led to a higher time in range by 4.3 percentage points (5.5, P = 0.02), lower insulin usage by 12.2 U [16.2, 5.4] ( P = 0.008) and lower carbohydrate intake by 50 g (35
The study also has other limitations
Given the high cost of current GLP-1 receptor agonists, some individuals might find it unaffordable to sustain long-term obesity treatment
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