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Collectively, through these multi-organ and multi-level regulatory interactions, L-citrulline establishes a robust pharmacological basis for its therapeutic application in OS-related pathologies ( 4 Antioxidant protective mechanisms of L-citrulline 4.1 Activation of the arginine-NO pathway L-citrulline mediates its principal protective effects predominantly through the arginine-NO pathway

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10.1038/s41598-022-21388-w 87 PalaciosJ