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Ultimately, by inhibiting abnormal proliferation of PASMCs and endothelial cells, reducing extracellular matrix deposition, and improving myocardial energy metabolism patterns, it achieves the therapeutic goal of delaying pulmonary vascular remodeling and the progression of right heart failure, providing a unique multi-dimensional regulatory strategy of natural drugs for PH treatment

Furthermore, the resulting chlorinative stress may lead to multiorgan damage in COVID-19 through various mechanisms, including oxygen competition for heme-binding sites, decreased oxygen saturation, hemoglobin-heme iron oxidation, heme degradation, and iron release [88]

References Wilding JPH, et al

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