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But why has no synthetic pathway evolved that leads directly to the synthesis of L-malate

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doi: 10.1152/ajpcell.00375.2021 3 TaquetMDerconQLucianoSGeddesJRHusainMHarrisonPJ

Modulation of eating behavior and more sustained insulin action combined with reduced glucagon secretion leads to lower blood glucose levels and the creation of an energy deficit, forcing cells to seek alternative routes for energy production

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