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During apoptosis, the BAX/BAK pores permit protrusion or herniation of the inner mitochondrial membrane, carrying mitochondrial matrix content, including mtDNA, into the cytosol [76]

This weakens immune function and allows toxins to build up in the body, resulting in toxic overload, disease, and premature aging

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Progress and challenges in translating the biology of aterosclerosis

Chronic treatment with DHF (6 g/day) in murine models demonstrated reduced eosinophilic pulmonary inflammation, serum IgE, IL-4 and IL-13 levels and an increase in IFN- production in cell cultures from the lung in response to antigen stimulation [112]