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Some researchers prefer to administer the capsules in the morning, while others may divide the dosage throughout the day

For example, people who are experiencing loss of kidney function due to diabetes may find that high strength B12 supplementation can cause the loss of function to speed up (House et al., 2010), and high dose supplements of B12 may also increase the risk of colon cancer in older people

And while the MTHFR variants primarily impact folate metabolism, the interconnectedness of the methylation cycle means that it indirectly affects vitamin B12 utilization as well

Source: Allen, L

Aftercare No downtime is needed