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Annals of Oncology 29(Suppl 8), 2018

The hexokinase -VDAC1 association favors cancer cell survival through at least two mechanisms: (i) evading apoptosis 79 , and (ii) diminishing the negative feedback inhibition of the enzyme by glucose-6-phosphate 80,81,82,83,84

While each has been studied independently with promising preclinical results, the combination has attracted significant research interest due to their complementary mechanisms of action

Mechanism of Action: Research suggests it promotes angiogenesis (new blood vessel formation), collagen synthesis, and cellular signaling pathways that accelerate recovery

As a pH adjuster, it's typically used well under 1% though regulatory caps go much higher: 5% in nail cuticle removers and 2-4.5% in hair straighteners