optic neuritis glp 1 NAION and GLP1s: Rare Cause of Blindness Linked to Medication | Michael Weintraub, MD posted on the topic Semaglutide Associated With Optic Neuropathy

With a mean follow-up of 2.6 years, the study demonstrated a 34% reduction in the relative risk (RR) of a composite renal outcome, including dialysis requirement, a decline in glomerular filtration rate (GFR) 7% were initiated on the complementary drug to complete the GLP-1 RA + SGLT-2i combination therapy

A handful of studies and simulations, though, suggest that any future health savings will still be dwarfed by the cost of the drugs, at least at current prices

The company states they provide "insulin-sized needles, making the injection process easy and virtually painless." This safety overview is not exhaustive and does not replace a conversation with your prescribing clinician

Metabolic benefits at low doses Even at microdose levels, GLP-1R agonists improve glucose variability, reducing post-meal blood glucose spikes

For those on warfarin, INR monitoring is advisable, and effects on other oral medicines with narrow therapeutic indices should be considered due to delayed gastric emptying