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D-Nle-X-Ile-NH-(CH 2 )s~CONH 2 analogs modify HGF/Met mediated cell scattering in MDCK cells Cell scattering is the hallmark effect of HGF/Met signaling

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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction