Tobacco use has seen a significant decline in Australia in recent decades, but vape and e-cigarette use has risen sharply, particularly among young people
Bracketing allows sponsors to rely in part on the agencys previous finding of safety for the higher nicotine exposure drug product and the agencys previous finding of effectiveness for the lower nicotine exposure drug product

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Reproductive Biology and Endocrinology , 18 (1), 1-11
She said the FDAs proposal centers on human studies that have shown that if you lower the nicotine content below a certain threshold, people will just stop smoking cigarettes on their own