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Given the far higher return on investment for movie makers for youth versus R-rated movies, it is hoped that R-rated restrictions would provide an economic incentive to reduce smoking content

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However, there were also some shared patterns between the genes whose expression is smoking-associated and the smoking-related hypomethylation pattern

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Martins RA, Cunha MR, Neves AP, Martins M, Teixeira-Verissimo M, Teixeira AM