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The harms to pregnancy from smoking, in late pregnancy at least, seem to be due to other chemicals in tobacco smoke rather than nicotine." The study, conducted by researchers at Queen Mary University of London, University of New South Wales (Australia), University of Nottingham, St Georges University of London, University of Stirling, University of Edinburgh, and Kings College London, and St Georges University Hospitals NHS Foundation Trust, analysed data collected in the Pregnancy Trial of E-cigarettes and Patches (PREP) randomised controlled trial, funded by the National Institute for Health and Care Research (NIHR).

As a result of such many-stage processing, all noxious impurities and toxins are removed from tobacco, and this significantly improves the product quality