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The causal effect of alcoholrelated DNA methylation CpG loci on QT interval predisposition Given the observed causal relationship between DrnkWk and prolonged QT intervals, and the fact that EWAS suggests that drinking influences DNA methylation in blood and tissues, and that aberrant epigenetic mechanisms (patterns of DNA methylation) potentially modulate a wide range of cardiovascular disorders, including cardiac arrhythmias [26,27,28], using GCTA results, we identified 65 SNPs associated with 56 CpG sites from the mQTLdb database, all of them belonging to cis-mQTL (Table S4)