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This amounted to what Hajek called extremely large doses of nicotine. At the end of the three months, Tang found DNA damage in the hearts, lungs and bladders of mice exposed to the vapours that was not evident in a control group of animals that breathed filtered air

Although more nicotine is extracted from the lozenge than the NP (100% vs 62%), the similar C max and AUC 0-T values observed for the NP and lozenge suggests that absorption of released nicotine is greater from the pouch than the lozenge

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