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Even as their use approaches some of the lowest points in the modern era, cigarettes are believed to be responsible for killing tens of thousands of Americans every year

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In a very recent study, chronic administration of nicotine to mice (1 mg/kg every 3 days for a 60-day period) enhanced brain metastasis by skewing the polarity of M2 microglia, which increases metastatic tumour growth [50]

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