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It works best when combined with a structured plan that includes lifestyle coaching, dietary changes, and physical activity

Given that cardiovascular disease is a leading cause of death in MASLD/MASH [1,2] , these parallel cardiometabolic benefits confer additional target-organ protection, further reinforcing the appeal of semaglutide in this high-risk population

However, challenges such as metabolic side effects and short half-life necessitate innovative delivery strategies, including Pegylation and gene therapy, to optimize its clinical application

Metabolic effects may persist slightly longer, up to 8 weeks post-discontinuation

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