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The specific rules vary widely by jurisdiction and industry

2021;268(Pt B):115863

Without medical supervision, this can be deadly

Further oxidation of Hz and AcHz by CYP450 enzymes, particularly CYP2E1, generates reactive intermediates that form covalent adducts with endogenous macromolecules, a process implicated in INH-induced hepatotoxicity (Delaney and Timbrell, 1995