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Patients: A total of 9650 adult patients with established CV disease without CKD (56.7%), CKD only (13%), or both CV disease and CKD (27%) were randomized 1:1 to receive semaglutide tablets 14 mg (n=4825) or placebo (n=4825) once daily, both in addition to standard-of-care treatments for glycemic control and CV risk factors including blood pressure medication, lipid-lowering agents, and antiplatelet/anticoagulant therapy