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"While further research is needed, liraglutide may work through various mechanisms, such as reducing inflammation in the brain, lowering insulin resistance and the toxic effects of Alzheimer's biomarkers amyloid-beta and tau, and improving how the brain's nerve cells communicate." One thing liraglutide didn't appear to do for the patients in this trial was meaningfully improve their brain's glucose metabolism, which is another key part of dementia progression

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The TJ and gut permeability The TJ (also referred to as zonula occludens ) is the most apical cell-to-cell adhesion between neighboring epithelial and endothelial cells

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