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One study looked at 16 patients with fibromyalgia and compared them to 15 control subjects without fibromyalgia using MRI scans of the brain

The only definitive sign is the beyond-use date stamped by the pharmacy or a known temperature excursion (vial left out for more than 4 hours or frozen)

Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1/TFAM pathway in human umbilical vein endothelial cells (HUVECs)

"very low" means the true effect could differ substantially from what the pooled estimate suggests