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Author contributions XD performed the data analysis and wrote the original manuscript

(1998) showed no significant cortisol or ACTH elevation even at 200 times the effective GH-releasing dose

Based on experiments with this organoid model of small airway epithelia, and comparisons with 16HBE14o- and other cell types expressing normal CFTR, we predict that inflammation in the COVID-19 airway may be mediated by inhibition of CFTR signaling by the SARS-CoV-2 spike protein, thus inducing a cystic fibrosis-like clinical phenotype