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Spatial omics technologies, particularly the 10x Visium platform, have enabled simultaneous profiling of mitochondrial metabolic states and immune cell infiltration patterns at anatomical resolution, facilitating the initial construction of spatially resolved metabolismimmune interaction maps [168].In parallel, proteomics is increasingly recognized as a critical complement to transcriptomic and metabolomic data

22 of the subjects completed the study (74)

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First, isolate newly identified microbial metabolites that modulate systemic FTN homeostasis, establish their molecular targets and signaling cascades in intestinal epithelial cellsin particular, how they interact with the dimerization of HIF-2/ARNT

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