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doi: 10.3389/fendo.2025.1696419 Received 31 August 2025 Revised 30 October 2025 Accepted 04 November 2025 Published 17 December 2025 Volume 16 - 2025 Edited by Lei Sha, China Medical University, China Reviewed by Maria Claudia Gonzalez Deniselle, CONICET Institute of Biology and Experimental Medicine (IBYME), Argentina Federica Ferrari, University of Pavia, Italy Updates Copyright 2025 Giofr, Zaffina, Pelle and Arturi

This dose is higher than that usually used in congenital GHD, but lower doses showed a reduced effect on body composition (126, 127)

Skin reactions, Gastrointestinal problems, and Drug interactions

These low doses help your body adjust and reduce the risk of possible gastrointestinal side effects such as nausea, vomiting, diarrhea and constipation

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