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510 Hyperactive ERAD and IRE1 signaling in synovial inflammation and cell survival in RA In RA, hyperactivation of the ERAD system, known as hyper-ERAD, contributes to synoviocyte proliferation and mitigates severe ER stress by promoting an anti-apoptotic response

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(A) qPCR data showing the normalized mRNA expression of NRF2-regulated genes ( Gclm , Nqo1 , Srxn1 , Hmox1 , Gsr ) in RAW264.7 Ms with (+) and without (-) oxLDL loading and LPS stimulation for 6 h (n = 45)

Ho XD, Nguyen HG, Trinh LH, et al

Metabolomics and lipidomics datasets supporting the findings of this study are provided in Supplementary Table 12