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Clinical trials involving children with ASD have shown that bumetanide not only alleviates the severity of ASD symptoms but also reduces GABA concentrations in the insular cortex

doi: 10.1101/2024.02.11.24302636 65 GaeblerCWangZLorenziJCCMueckschFFinkinSTokuyamaMet al

As coactivators that connect acetylated transcription factors and histones to the activation of RNA polymerase II, the bromodomain and extra-terminal domain (BET) family proteins preferentially promotes the transcription of oncogenes such as Myc, HER3, MET, and IGF-IR [136,137,138]

doi: 10.1038/s41575-018-0061-2, 130

Your plan should be reviewed over time