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For example, CJC1295 No DAC activates GHRH receptors in the pituitary, and Ipamorelin targets the ghrelin (GHSR1a) receptor in test models

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Superoxide anion radical (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO), and singlet oxygen ( 1 O 2 ) are the sources of ROS in neurons

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It is worth emphasizing that the hypoxia microenvironment induced by the E-P-OS network itself can directly activate the transcription of glycolysis-related genes such as glucose transporter 1 and lactate dehydrogenase A via HIF-1, thereby further enhancing glycolysis and ensuring energy supply for fibroid cells under hypoxic conditions [108]