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Caspase-4/5/11 can also activate the NLRP3 inflammasome, which subsequently activates caspase-1, resulting in the production and release of IL-1 and IL-18 (Sahoo et al., 2023)

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GLP-1RA or dual GIP/GLP-1RA added to basal insulin provides a relevant weight reduction compared to basal insulin titration with a rigorous intention-to-treat approach ( weight = -3.95 kg, 95% CI -5.1, -2.79, I 2 96%)