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As treatment extends beyond three years, clinicians must consider how gastrointestinal tolerability evolves over time

When estrogen levels dip in perimenopause, ghrelin levels rise and, as a result, so do appetite, cravings for carbs, sweets, and fast food, and the accumulation of belly fat

On the other hand, GLP-2 analogs due to their effects on crypt cell proliferation, improving intestinal expansion and nutrient absorption, are used for intestinal injury and short bowel syndrome (Litvak et al