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Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

Among the four completed trials, two (LEADER and SUSTAIN-6) demonstrated significant risk reduction in MACE [2, 3], and one (EXSCEL) demonstrated a numerically reduced risk of MACE [28]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Wen C., et al