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reported that Shaoyao-Gancao Decoction (SGD), commonly used to treat multiple gynecological disorders such as dysmenorrhea, adenomyosis, and PCOS, modulated gut microbiota composition, and alleviated chronic low-grade inflammation by downregulating cytokines including IL-18, IL-1, IL-6, and TNF- in both serum and ovarian mRNA expression in PCOS rats (238)

These saponin components act through multiple targets and pathways, including anti-oxidative stress, anti-inflammatory, and anti-apoptotic mechanisms

Cartilage & Joint Research Kwon and Park, Annals of Clinical and Laboratory Science (2015) Kwon and Park investigated the chondroprotective effects of intra-articular AOD-9604 administration in a rabbit model of osteoarthritis, with and without co-administration of hyaluronic acid

The choice between sterile saline and bacteriostatic water depends on the specific medical situation

doi: 10.3389/fmicb.2024.1328324 46 GracieDJHamlinPJFordAC