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Titration, the process of slowly increasing dosage over time and only when the medication is well-tolerated, helps manage GLP-1 side effects

for example, we know GLP-1s can increase the risk of gastrointestinal complications and pancreatitis

This is a critical proof-of-concept that GLP-1 RAs effects are not mediated solely through glycemic control but may involve direct modulation of vascular inflammation, endothelial dysfunction, and myocardial energetics

People familiar with how Zepbound works understand the importance of proper medication handling