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Jos Esprito Santo, Lote 49, Loja 1, Chelas, 1900-672 LISBOA, PORTUGAL Telephone: + 351-218371699 Fax: + 351-218371712 E-mail: [email protected] Acknowledgements This article is based on a paper presented at the International Conference on Chromosome 21 and Medical Research on Down Syndrome, Barcelona, 1997

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Median age at onset in patients with BRIC-1 was 12 years while BRIC-2 was 1 month